CAS 110-54-3 · TSCA · United States of America

n-Hexane under TSCA

C6H14 · 正己烷

Status: Listed. n-Hexane is on the TSCA Inventory and currently listed as TSCA Active. **OSHA PEL for n-hexane at 29 CFR 1910.1000 Table Z-1: 500 ppm 8-hr TWA (verified against https://www.osha.gov/annotated-pels/table-z-1); NIOSH REL substantially lower: 50 ppm 8-hr TWA reflecting peripheral neuropathy concern (ACGIH TLV also 50 ppm with skin notation; verify NIOSH against cdc.gov/niosh).** NOT on EPA RMP threshold list. NOT on DEA scheduling. **On California Proposition 65 list: n-hexane listed 15 December 2017 for Male Reproductive Toxicity (verify against OEHHA https://oehha.ca.gov/proposition-65/chemicals/n-hexane before invoicing); Prop 65 warning trigger applies for consumer-product exposures above the OEHHA-set Maximum Allowable Dose Level for male reproductive toxicity (verify the MADL value against OEHHA before relying).** NO active US AD/CVD case on Chinese-origin n-hexane currently (verify against https://access.trade.gov/ before invoicing). Section 301 List 3 25% additional duty applies on Chinese-origin n-hexane (HS 290110) (verify against current USTR Section 301 schedule before invoicing). **FDA 21 CFR 173.270 lists hexane as a permitted indirect food additive solvent for spice extraction + hops extraction + oilseed extraction with residue limits (verify current 21 CFR 173.270 against https://www.ecfr.gov/ before relying)**. Major US domestic producers (typically integrated with refinery / petrochemical complexes; verify each company-site pair against the producer's public website before relying): ExxonMobil Baytown Texas plus Beaumont Texas, Phillips 66 Sweeny Texas, Marathon Petroleum Galveston Bay Texas plus Garyville Louisiana, Valero Energy Port Arthur Texas plus Corpus Christi Texas.

US n-hexane lane: **OSHA PEL 500 ppm but NIOSH REL substantially lower 50 ppm (peripheral neuropathy concern from 2,5-hexanedione metabolite; ACGIH TLV also 50 ppm with skin notation) + Cal Prop 65 listed 15 December 2017 for Male Reproductive Toxicity + Section 301 List 3 + FDA 21 CFR 173.270 indirect food additive solvent for spice / hops / oilseed extraction**. NO active US AD/CVD case. IARC Group 3 per Volume 71 (1999). Major US producers: ExxonMobil, Phillips 66, Marathon Petroleum, Valero (Texas + Louisiana refineries).

Listing and threshold

Substance n-Hexane (CAS 110-54-3), C6H14
Regime US Toxic Substances Control Act (TSCA), administered by EPA
Jurisdiction United States of America
Status Listed
Tonnage threshold CDR threshold: 25,000 lb manufactured or imported per site per year

Classifications under this regime

  • OSHA HCS: Repr. 2 + STOT RE 2 peripheral neuropathy + Asp. Tox. 1 + Flam. Liq. 2 + Aquatic Chronic 2
  • OSHA PEL: 500 ppm 8-hr TWA at 29 CFR 1910.1000 Table Z-1 (verified against https://www.osha.gov/annotated-pels/table-z-1)
  • NIOSH REL: 50 ppm 8-hr TWA (peripheral neuropathy concern; verify against cdc.gov/niosh)
  • ACGIH TLV: 50 ppm 8-hr TWA with skin notation (verify against current ACGIH TLV booklet)
  • NOT subject to TSCA Section 6 Risk Evaluation
  • NOT on EPA RMP threshold list
  • NOT on DEA List I or List II
  • On California Proposition 65 list: n-hexane listed 15 December 2017 for Male Reproductive Toxicity (verified against OEHHA https://oehha.ca.gov/proposition-65/chemicals/n-hexane)
  • DOT 49 CFR 172.101: UN 1208 Class 3 PG II
  • **FDA 21 CFR 173.270 indirect food additive solvent** for spice + hops + oilseed extraction with residue limits (verify against https://www.ecfr.gov/)
  • IARC Group 3 (not classifiable)

Restrictions and conditions of use

  • NO active US AD/CVD case on Chinese-origin n-hexane currently
  • Section 301 List 3 25% additional duty applies on Chinese-origin n-hexane (HS 290110)
  • OSHA PEL 500 ppm 8-hr TWA applies (NIOSH REL 50 ppm substantially more protective)
  • FDA 21 CFR 173.270 indirect food additive solvent residue limits for spice + hops + oilseed extraction

Importer obligations

TSCA self-certification regime. Major US producers (typically integrated with refinery; verify each producer-site pair before relying): ExxonMobil Baytown TX + Beaumont TX, Phillips 66 Sweeny TX, Marathon Petroleum Galveston Bay TX + Garyville LA, Valero Energy Port Arthur TX + Corpus Christi TX.

Required documents

  • TSCA Section 13 Import Certification on customs entry
  • OSHA SDS (Repr. 2 + STOT RE 2 peripheral neuropathy + Asp. Tox. 1 + Flam. Liq. 2 hazard profile)
  • CBP Form 7501 with HS 290110 + Section 301 List 3 25% duty
  • CDR filing every 4 years
  • DOT documentation for UN 1208 Class 3 PG II
  • FDA 21 CFR 173.270 residue compliance for food-extraction grade

Common compliance traps

The pitfalls that have bitten importers on this lane in the past. None of these is theoretical.

  • OSHA PEL 500 ppm 8-hr TWA but **NIOSH REL substantially lower at 50 ppm reflecting peripheral neuropathy concern**
  • NO active US AD/CVD case on n-hexane
  • Section 301 List 3 25% additional duty applies
  • FDA 21 CFR 173.270 indirect food additive solvent residue limits for spice + hops + oilseed extraction
  • IARC Group 3 (not classifiable) per IARC Monograph Volume 71 (1999) (verify against monographs.iarc.who.int Volume 71 before relying)
  • **On California Proposition 65 list: n-hexane listed 15 December 2017 for Male Reproductive Toxicity (verified against OEHHA https://oehha.ca.gov/proposition-65/chemicals/n-hexane)**
  • Major US producers: ExxonMobil Baytown TX + Beaumont TX, Phillips 66 Sweeny TX, Marathon Petroleum Galveston Bay TX + Garyville LA, Valero Port Arthur TX + Corpus Christi TX (verify each producer-site pair)

Where to read next

For substance-level identifiers (formula, molecular weight, SMILES, InChIKey), GHS hazard profile, IMDG transport class, and full sourcing reference for n-hexane, see the CAS 110-54-3 sourcing reference.

For grade-by-grade buying notes, freight maths, supplier-tier pricing, and a worked landed-cost example, the n-hexane cornerstone hub covers the full sourcing chain.

For the structure and history of TSCA, see the TSCA glossary entry.

Need cross-jurisdiction compliance support on this substance? Run it through the REACH / TSCA / IECSC / AICIS / K-REACH checker, or send us the substance and the destination and we will quote FOB China and CIF / DDP landed including the regulatory work on the destination side.

Read next

Cross-jurisdiction profile and sourcing references

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