CAS 67-63-0 · REACH · European Union

Isopropyl alcohol (IPA, propan-2-ol) under REACH

C3H8O · 异丙醇

Status: Registered. IPA is fully registered under REACH at the highest tonnage band (>1,000,000 tonnes/year). **Distinguishing pattern: solvent applications (paint, ink, adhesive, pharmaceutical extraction, cosmetic, automotive antifreeze plus windscreen washer; ~70 percent combined) plus antiseptic and sanitiser (~20 percent; demand spiked during COVID-19 era 2020-2022) plus chemical feedstock (~10 percent; acetone via dehydrogenation, MIBK via condensation) + propylene batch 53 hydration production route (~95 percent globally; sulfuric acid-catalysed direct hydration plus indirect hydration sub-routes) + Flam. Liq. 2 plus Eye Irrit. 2 plus STOT SE 3 (NEW combined).** Reg (EC) 1272/2008 harmonised: Flam. Liq. 2 (H225) plus Eye Irrit. 2 (H319) plus STOT SE 3 (H336). NOT SVHC. NOT Annex XIV. NO active EU AD case on Chinese-origin IPA currently (verify against EUR-Lex https://eur-lex.europa.eu/ before invoicing).

IPA is fully REACH-registered with **light occupational hazard** (Flam. Liq. 2 + Eye Irrit. 2 + STOT SE 3 narcotic only). NOT SVHC, NOT Annex XIV, NO active EU AD. **Solvent applications dominate** (~70 percent of demand) plus **antiseptic and sanitiser** (~20 percent). EU Reg 528/2012 BPR active-substance approval for biocidal-product applications. Major Chinese producers: Sinopec multi-site, CNPC, Hengli Petrochemical Dalian, Wanhua Chemical Yantai, Tongling Henghao. Production: propylene batch 53 hydration (~95 percent globally).

Listing and threshold

Substance Isopropyl alcohol (IPA, propan-2-ol) (CAS 67-63-0), C3H8O
Regime EU Regulation (EC) No 1907/2006: Registration, Evaluation, Authorisation and Restriction of Chemicals
Jurisdiction European Union (EU-27 plus EEA: Iceland, Liechtenstein, Norway)
Status Registered
Tonnage threshold Registration required for any importer or manufacturer placing >1 t/year on the EU market

Classifications under this regime

  • Harmonised CLP classification: Flam. Liq. 2 (H225, "highly flammable liquid and vapour"), Eye Irrit. 2 (H319), STOT SE 3 (H336, narcotic-CNS effects)
  • Signal word: DANGER. GHS pictograms: GHS02 + GHS07
  • IARC: Group 3 (not classifiable; the substance IPA itself is Group 3 although the historical "strong-acid IPA manufacturing process" was IARC Group 1; verify against https://monographs.iarc.who.int/list-of-classifications)
  • NOT subject to Drug Precursors or Explosives Precursors scheduling under EU Reg 273/2004 (note IPA is NOT a Drug Precursors Cat substance unlike acetone batch 15 plus MEK plus toluene; IPA is regulated parallel under national-level retail-distribution rules in some Member States)
  • ADR / RID transport classification: Class 3 (flammable liquid), UN 1219 (isopropanol), Packing Group II

Restrictions and conditions of use

  • NOT on REACH Annex XIV (verify against ECHA https://echa.europa.eu/authorisation-list)
  • NOT classified as SVHC (verify against ECHA https://echa.europa.eu/candidate-list-table)
  • NOT subject to any Annex XVII restriction at industrial-grade level
  • NO active EU AD case on Chinese-origin IPA currently
  • NOT in CBAM Phase 1 scope
  • EU Reg 528/2012 Biocidal Products Regulation: IPA approved as biocidal active substance for product types 1 (human hygiene), 2 (private + public-area disinfection), 4 (food + feed area), Article 95 listing applies (verify current BPR approval status at https://echa.europa.eu/information-on-chemicals/biocidal-active-substances before relying)

Importer obligations

A non-EU producer cannot register directly under REACH. The EU importer of record must hold a registration or rely on an Only Representative (OR). Light occupational hazard otherwise. Major Chinese producers: Sinopec multi-site, CNPC, Hengli Petrochemical Dalian, Wanhua Chemical Yantai, Tongling Henghao (verify each producer-site pair against the producer's public website before relying on a specific plant).

Required documents

  • REACH registration number on EU side
  • SDS reflecting H225 / H319 / H336 classification
  • CLP labelling with GHS02 + GHS07 + DANGER
  • Customs entry HS code 290512 (propan-2-ol)
  • ADR consignment note Class 3, UN 1219, PG II
  • EU Reg 528/2012 BPR active-substance documentation for biocidal-product applications

Common compliance traps

The pitfalls that have bitten importers on this lane in the past. None of these is theoretical.

  • **Solvent applications dominate** (~70 percent of demand): paint, ink, adhesive, pharmaceutical extraction, cosmetic, automotive antifreeze plus windscreen washer
  • **Antiseptic and sanitiser demand** (~20 percent; volatility post-COVID-19 era 2020-2022)
  • EU Reg 528/2012 BPR active-substance approval for human-hygiene + disinfection + food/feed-area products
  • Light occupational hazard otherwise
  • NOT SVHC, NOT Annex XIV, NO active EU AD
  • Major Chinese producers: Sinopec multi-site, CNPC, Hengli Petrochemical Dalian, Wanhua Chemical Yantai, Tongling Henghao; China dominates global IPA capacity (verify percent-of-global share against ICIS or S&P Commodity Insights before quoting)
  • Production: propylene batch 53 hydration (~95 percent globally; sulfuric acid-catalysed direct hydration or indirect hydration sub-routes)

Where to read next

For substance-level identifiers (formula, molecular weight, SMILES, InChIKey), GHS hazard profile, IMDG transport class, and full sourcing reference for isopropyl alcohol (ipa, propan-2-ol), see the CAS 67-63-0 sourcing reference.

For grade-by-grade buying notes, freight maths, supplier-tier pricing, and a worked landed-cost example, the isopropyl alcohol (ipa, propan-2-ol) cornerstone hub covers the full sourcing chain.

For the structure and history of REACH, see the REACH glossary entry.

Need cross-jurisdiction compliance support on this substance? Run it through the REACH / TSCA / IECSC / AICIS / K-REACH checker, or send us the substance and the destination and we will quote FOB China and CIF / DDP landed including the regulatory work on the destination side.

Read next

Cross-jurisdiction profile and sourcing references

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