CAS 62-53-3 · REACH · European Union

Aniline (aminobenzene) under REACH

C6H7N · 苯胺

Status: Registered. Aniline is fully registered under REACH at the highest tonnage band (>1,000,000 tonnes/year). **Distinguishing pattern: MDI / TDI chain primary feedstock (~85% of aniline demand globally) + nitrobenzene hydrogenation route + benzene (batch 22) ultimate downstream chain + Carc 2 + Muta 2 + Acute Tox. 3 + STOT RE 1 (blood / spleen) + IARC Group 2B (possibly carcinogenic to humans) + Wanhua Chemical Yantai world's largest MDI producer integrated upstream into aniline (NEW combined).** Reg (EC) 1272/2008 harmonised classification includes Carc 2 + Muta 2 + Acute Tox. 3 (oral + dermal + inhalation) + STOT RE 1 (blood + spleen) + Skin Sens 1 + Eye Dam 1. NOT SVHC. NOT Annex XIV. NOT a drug precursor. NO active EU AD case on Chinese-origin aniline currently. Production route: nitrobenzene hydrogenation (~95% globally); nitrobenzene from benzene (batch 22) + nitric acid + sulfuric acid (batch 2).

Aniline carries **moderate-to-heavy regulatory burden**: Carc 2 + Muta 2 + Acute Tox. 3 + STOT RE 1 (blood + spleen) + IARC Group 2B (since 2021) + Aquatic Chronic 1. NOT SVHC despite Carc 2 (kept off because of essential industrial use including MDI / TDI chain ~85% of demand). NO active EU AD case. NOT in CBAM Phase 1. **Annex XVII Restriction 43** drives downstream textile + leather article compliance for azo-dye disclosure. Major Chinese producers: **Wanhua Chemical Yantai (the largest single-company MDI producer globally with integrated upstream aniline plus nitrobenzene plus nitric acid capacity; verify the most recent total MDI nameplate against the Wanhua Chemical investor site before quoting a specific Mt/yr figure)**, Sinopec Anqing, Sinopec Yanshan, Lanxess Shanghai, BASF Shanghai. Production route: nitrobenzene hydrogenation (~95% globally); nitrobenzene from benzene (batch 22) + nitric acid + sulfuric acid (batch 2). End-use mix dominated by MDI / TDI feedstock (~85%, world's largest single use), rubber processing chemicals (~5%), agrochemicals + dyes + pharmaceuticals (~10%). Wanhua Chemical Yantai integrated MDI chain dominates Chinese aniline economics structurally.

Listing and threshold

Substance Aniline (aminobenzene) (CAS 62-53-3), C6H7N
Regime EU Regulation (EC) No 1907/2006: Registration, Evaluation, Authorisation and Restriction of Chemicals
Jurisdiction European Union (EU-27 plus EEA: Iceland, Liechtenstein, Norway)
Status Registered
Tonnage threshold Registration required for any importer or manufacturer placing >1 t/year on the EU market

Classifications under this regime

  • Harmonised CLP classification: Carc. 2 (H351), Muta. 2 (H341), Acute Tox. 3 oral / dermal / inhalation (H301 / H311 / H331), STOT RE 1 (H372 blood + spleen), Skin Sens. 1 (H317), Eye Dam. 1 (H318), Aquatic Acute 1 (H400), Aquatic Chronic 1 (H410)
  • Signal word: DANGER
  • GHS pictograms: GHS06 (skull and crossbones), GHS08 (health hazard, target organ), GHS09 (aquatic environment)
  • **IARC: Group 2B (possibly carcinogenic to humans) per IARC Monograph 127, 2021** (upgraded from Group 3 prior; verify Volume 127 against https://monographs.iarc.who.int/list-of-classifications)
  • NOT subject to Drug Precursors or Explosives Precursors scheduling
  • ADR / RID transport classification: Class 6.1 (toxic substance), UN 1547, Packing Group II

Restrictions and conditions of use

  • NOT on REACH Annex XIV (Authorisation list)
  • NOT classified as SVHC (despite Carc 2 classification, kept off SVHC because of essential industrial use including MDI / TDI chain)
  • **Annex XVII Restriction 43** (Reg 1907/2006 Annex XVII as amended by Reg 552/2009): aniline plus 22 specific aromatic amines from azo dyes >30 mg/kg in textile plus leather articles in direct plus prolonged contact with human skin restricted (verify the consolidated Annex XVII text and the current entry-43 list of regulated aromatic amines against EUR-Lex https://eur-lex.europa.eu/eli/reg/2006/1907/oj before relying on aniline-specific scope)
  • NO active EU AD case on Chinese-origin aniline currently
  • Carbon Border Adjustment Mechanism (CBAM): NOT in CBAM Phase 1 scope; potential Phase 2 candidate post-2026 review
  • EU Reg 10/2011 food-contact: aniline NOT permitted in plastic food-contact materials
  • EU Cosmetic Products Regulation 1223/2009 Annex II: aniline prohibited in cosmetic products

Importer obligations

A non-EU producer cannot register directly under REACH. The EU importer of record must hold a registration or rely on an Only Representative (OR). **Carc 2 + Muta 2 + Acute Tox. 3 + STOT RE 1 (blood + spleen) + Aquatic Chronic 1 hazard profile drives substantial workplace exposure-control + waste-discharge overhead**. **Annex XVII Restriction 43** drives downstream compliance for textile + leather article importers (azo-dye disclosure). Major Chinese producers (Wanhua Chemical Yantai, Sinopec Anqing + Sinopec Yanshan, Lanxess Shanghai, BASF Shanghai, Sailing Chemical) compete with EU domestic producers (BASF Ludwigshafen + BASF Antwerp, Covestro Brunsbüttel + Covestro Krefeld + Covestro Tarragona, Huntsman Geismar Louisiana). The dominant economic story for Chinese-origin aniline is **Wanhua Chemical Yantai integrated MDI chain**: Wanhua produces a leading volume of MDI globally and consumes most of its own aniline upstream (verify the most recent total Wanhua MDI nameplate against the Wanhua Chemical investor site before quoting world-largest rank or a specific Mt/yr figure).

Required documents

  • REACH registration number on the EU side (registrant or OR-appointed)
  • Safety Data Sheet (SDS) compliant with REACH Annex II in destination Member State language(s) reflecting H301 / H311 / H317 / H318 / H331 / H341 / H351 / H372 / H410 classification
  • CLP-compliant labelling with GHS06 + GHS08 + GHS09 pictograms and DANGER signal word
  • Customs entry with HS code 292141 (aniline)
  • ADR consignment note for transport (Class 6.1, UN 1547, PG II)
  • Annex XVII Restriction 43 compliance documentation for downstream textile + leather article importers (azo-dye disclosure)

Common compliance traps

The pitfalls that have bitten importers on this lane in the past. None of these is theoretical.

  • **Carc 2 + Muta 2 + Acute Tox. 3 + STOT RE 1 (blood + spleen) hazard profile** drives substantial workplace exposure-control + waste-discharge overhead
  • **Aquatic Chronic 1 (H410)** drives wastewater treatment + discharge compliance for downstream MDI / TDI / dyestuff manufacturers
  • NOT SVHC despite Carc 2 (kept off because of essential industrial use including MDI / TDI chain ~85% of demand)
  • NO active EU AD case on Chinese aniline currently
  • NOT in CBAM Phase 1 scope
  • Major Chinese producers: Wanhua Chemical Yantai (Shandong; the largest single-company MDI producer globally with integrated upstream aniline plus nitrobenzene plus nitric acid capacity; verify the most recent total MDI nameplate against the Wanhua Chemical investor site before quoting world-largest rank or a specific Mt/yr figure), Sinopec Anqing (Anhui), Sinopec Yanshan (Beijing), Lanxess Shanghai, BASF Shanghai, Sailing Chemical
  • Production route: nitrobenzene hydrogenation (~95% globally); nitrobenzene from benzene (batch 22) + nitric acid + sulfuric acid (batch 2)
  • **Wanhua Chemical Yantai integrated MDI chain dominates Chinese aniline economics**: Wanhua produces a leading volume of MDI globally and consumes most of its own aniline upstream (verify the most recent total Wanhua MDI nameplate against the Wanhua Chemical investor site before quoting world-largest rank or a specific Mt/yr figure)
  • End-use mix: MDI / TDI feedstock (~85%, world's largest single use), rubber processing chemicals (~5%), agrochemicals + dyes + pharmaceuticals (~10%)
  • Annex XVII Restriction 43 (azo dyes in textile + leather >30 mg/kg) is the dominant downstream finished-product compliance layer

Where to read next

For substance-level identifiers (formula, molecular weight, SMILES, InChIKey), GHS hazard profile, IMDG transport class, and full sourcing reference for aniline (aminobenzene), see the CAS 62-53-3 sourcing reference.

For grade-by-grade buying notes, freight maths, supplier-tier pricing, and a worked landed-cost example, the aniline (aminobenzene) cornerstone hub covers the full sourcing chain.

For the structure and history of REACH, see the REACH glossary entry.

Need cross-jurisdiction compliance support on this substance? Run it through the REACH / TSCA / IECSC / AICIS / K-REACH checker, or send us the substance and the destination and we will quote FOB China and CIF / DDP landed including the regulatory work on the destination side.

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Cross-jurisdiction profile and sourcing references

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