CAS 141-78-6 · TSCA · United States of America

Ethyl acetate under TSCA

C4H8O2 · 乙酸乙酯

Status: Listed. Ethyl acetate is on the TSCA Inventory as a grandfathered pre-1979 substance and is currently listed as TSCA Active. No PMN is required. **OSHA PEL 400 ppm 8-hr TWA** at 29 CFR 1910.1000 Table Z-1 (verify against https://www.osha.gov/annotated-pels). NOT on EPA RMP threshold list. NOT on DEA scheduling. NOT on California Proposition 65 (verify against OEHHA https://oehha.ca.gov/proposition-65/proposition-65-list before relying on negative listing). NOT on TRI Section 313 list. NO active US AD/CVD case on Chinese-origin ethyl acetate currently (verify against https://access.trade.gov/ before invoicing). Section 301 List 3 25% additional duty applies on Chinese-origin ethyl acetate (HS 291531). FDA 21 CFR 184.1825 GRAS for food use; FDA 21 CFR 175 plus 177 indirect food-additive applications (verify exact 21 CFR section against https://www.ecfr.gov/ before relying).

The US ethyl acetate lane has the **lightest US-side regulatory profile in the dataset for an organic substance**: NOT on TRI, NOT on Cal Prop 65, NOT on DEA, NO active AD. Section 301 List 3 25% additional duty applies but is the only tariff-stack layer. OSHA PEL 400 ppm 8-hr TWA is moderate. Major US domestic producers: Celanese Pampa Texas, LyondellBasell Pasadena Texas, Eastman Chemical Kingsport Tennessee. US is structurally **net-importer** of ethyl acetate from Korean / Chinese / Brazilian supply (ethanol-route Brazilian + Indian producers have sugarcane / molasses ethanol cost advantages). FDA 21 CFR 184.1825 GRAS for food use. **Ethyl acetate distinguishing pattern in US lane**: lightest regulatory stack of any organic substance in the dataset; structurally net-imported from cost-advantaged ethanol-route producers (Brazil + India) and Section-301-stacked Chinese supply.

Listing and threshold

Substance Ethyl acetate (CAS 141-78-6), C4H8O2
Regime US Toxic Substances Control Act (TSCA), administered by EPA
Jurisdiction United States of America
Status Listed
Tonnage threshold CDR (Chemical Data Reporting) threshold: 25,000 lb (11,340 kg) manufactured or imported per site per year

Classifications under this regime

  • OSHA Hazard Communication Standard (HCS): GHS H225 / H319 / H336
  • OSHA PEL 29 CFR 1910.1000 Table Z-1: 400 ppm 8-hr TWA (per https://www.osha.gov/annotated-pels)
  • NIOSH REL: 400 ppm 8-hr TWA (verify against https://www.cdc.gov/niosh/npg/)
  • NOT subject to TSCA Section 6 Risk Evaluation
  • NOT on TSCA Section 5(a)(2) Significant New Use Rule list
  • NOT on EPA RMP threshold list
  • NOT on DEA List I or List II
  • NOT on California Proposition 65 list (verify against OEHHA https://oehha.ca.gov/proposition-65/proposition-65-list before relying on negative listing)
  • NOT on TRI Section 313 list
  • DOT hazardous materials regulation (49 CFR 172.101): UN 1173, Class 3, PG II
  • IARC: not classified
  • FDA 21 CFR 184.1825 GRAS for food use; FDA 21 CFR 175 + 177 indirect food-additive applications

Restrictions and conditions of use

  • No TSCA-specific use restrictions for ethyl acetate
  • OSHA-compliant SDS and workplace HazCom training required
  • NO active US AD/CVD case on Chinese-origin ethyl acetate currently
  • Section 301 List 3 25% additional duty applies on Chinese-origin ethyl acetate (HS 291531)
  • NFPA 30 Flammable and Combustible Liquids Code applies for storage
  • FDA 21 CFR 184.1825 approves ethyl acetate as food GRAS

Importer obligations

TSCA is a self-certification regime: importers attest at customs entry that the substance is on the TSCA Inventory. The dominant practitioner-facing layer for ethyl acetate is **Section 301 List 3 25% additional duty + OSHA HazCom training + NFPA storage compliance**. NO active AD/CVD case. NOT on TRI, NOT on Cal Prop 65, NOT on DEA. Lighter trade-policy and downstream compliance overhead than most other organic chemicals in the dataset. Major US domestic producers: Celanese Pampa Texas + LyondellBasell Pasadena Texas + Eastman Chemical Kingsport Tennessee. US is structurally net-importer of ethyl acetate from Korean / Chinese / Brazilian supply (ethanol-route producers in Brazil + India have cost advantages from sugarcane / molasses ethanol).

Required documents

  • TSCA Section 13 Import Certification statement on customs entry
  • OSHA-compliant SDS reflecting H225 / H319 / H336 classification
  • Customs entry CBP Form 7501 with HS code 291531 (ethyl acetate) and Section 301 List 3 25% duty applied
  • CDR filing every 4 years if site exceeds 25,000 lb/yr threshold (next cycle 2026)
  • NFPA 30-compliant storage tank engineering documentation for bulk receipt
  • FDA 21 CFR 184.1825 GRAS conformity declaration for food-grade lots

Common compliance traps

The pitfalls that have bitten importers on this lane in the past. None of these is theoretical.

  • **Lightest US-side regulatory profile in the dataset for an organic substance**: NOT on TRI, NOT on Cal Prop 65, NOT on DEA, NO active AD
  • OSHA PEL 400 ppm 8-hr TWA is moderate (lighter than benzene 1 ppm + formaldehyde 0.75 ppm, on par with acetone batch 15 250-1000 ppm range)
  • Section 301 List 3 25% additional duty applies; structurally lighter than caprolactam batch 14 + acetic acid batch 19 lanes
  • Major US domestic producers: Celanese Pampa Texas, LyondellBasell Pasadena Texas, Eastman Chemical Kingsport Tennessee
  • US is structurally net-importer of ethyl acetate from Korean / Chinese / Brazilian supply (ethanol-route Brazilian + Indian producers have sugarcane / molasses ethanol cost advantages)
  • FDA 21 CFR 184.1825 GRAS for food use; food-grade and pharmaceutical-grade lots dominate downstream applications
  • NFPA 30 Flammable and Combustible Liquids Code applies for storage (Flam. Liq. 2)

Where to read next

For substance-level identifiers (formula, molecular weight, SMILES, InChIKey), GHS hazard profile, IMDG transport class, and full sourcing reference for ethyl acetate, see the CAS 141-78-6 sourcing reference.

For grade-by-grade buying notes, freight maths, supplier-tier pricing, and a worked landed-cost example, the ethyl acetate cornerstone hub covers the full sourcing chain.

For the structure and history of TSCA, see the TSCA glossary entry.

Need cross-jurisdiction compliance support on this substance? Run it through the REACH / TSCA / IECSC / AICIS / K-REACH checker, or send us the substance and the destination and we will quote FOB China and CIF / DDP landed including the regulatory work on the destination side.

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Cross-jurisdiction profile and sourcing references

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